Endocrine Treatment of Advanced Breast Cancer

Endocrine treatment of advanced breast cancer.

Endocrine treatment is the preferred first-line therapy for advanced breast cancer because of its good tolerability. There are several groups of agents which differ in their mode of action but almost all in some way reduce stimulation by oestrogen. Over recent years, there has been a substantial increase in the number of medical agents in clinical trial. New antioestrogens with reduced or no ag...

[Endocrine therapy for advanced breast cancer].

The demonstrated efficacy of pharmacologic antiestrogen therapy in treating hormone receptor-positive breast cancer has changed the landscape of treatment for the majority of women with metastatic disease, providing them with a well-tolerated therapeutic alternative to surgical oophorectomy and chemotherapy. A multitude of clinical trials have evaluated the various endocrine agents alone or in ...

Surgical endocrine ablation for advanced breast cancer.

Neoadjuvant Endocrine Treatment for Breast Cancer

25/18_suppl/538; cited December 9, 2013] 35. Ali AM, Provenzano E, Bartlett JM. et al. Prognosis of early breast cancer by immunohistochemistry defined intrinsic sub-types in patients treated with adjuvant chemotherapy in the neat/br9601 trial. Int J Cancer 2013;133:1470–8. 36. Ellis MJ, Tao Y, Luo J, et al. Outcome prediction for estrogen receptor–positive breast cancer based on postneoadjuvan...

Efficacy and safety of endocrine monotherapy as first-line treatment for hormone-sensitive advanced breast cancer

BACKGROUND Endocrine therapy was recommended as the preferred first-line treatment for hormone receptor-positive (HR+, i.e., ER+ and/or PgR+), human epidermal growth factor receptor-2-negative (HER2-) postmenopausal advanced breast cancer (ABC), but which endocrine monotherapy is optimal lacks consensus. We aimed to identify the optimal endocrine monotherapy with a network meta-analysis. METH...